Job Description
Position: Drug hunters (chemists) or toxicologists
Type: Hourly contract
Compensation: $70-$100 per hour
Location: Remote
Commitment: 10–40 hours/week
- Role Responsibilities
- Review and annotate datasets related to drug discovery, pharmacology, and safety biology
- Interpret experimental outputs from target biology studies, biochemical assays, cellular models, and safety screens
- Analyze relationships between compound structure, potency, selectivity, exposure, and toxicity signals
- Identify mechanistic explanations behind efficacy or toxicity findings across discovery experiments
- Distinguish meaningful biological signal from experimental artifacts, assay interference, or model limitations
- Audit annotated datasets for biological, pharmacological, and safety accuracy
- Validate structure–activity relationships, target engagement logic, and pharmacokinetic interpretations
- Evaluate AI-generated reasoning on drug mechanism, toxicity risk, and safety margins
- Ensure correct interpretation of dose-response relationships, exposure margins, and translational relevance
- Contribute to annotation guidelines for drug discovery workflows, SAR, pharmacokinetics, toxicity mechanisms, and translational biology
- Provide expertise on balancing potency, selectivity, safety, and developability
- Advise on classification of toxicity findings, safety signals, and risk assessment frameworks
- Review AI-generated reasoning on drug mechanism, target biology, toxicity, and pharmacokinetics
- Assess whether conclusions logically follow from experimental evidence and biological context
- Provide structured feedback to improve scientific rigor and reasoning in model outputs
- Contribute to scientific standards documentation and training materials
- Help define gold‑standard examples of drug discovery reasoning and toxicity interpretation
- Support calibration workflows across pharmacology, toxicology, and translational biology
- Requirements
- Advanced degree such as PhD, PharmD, DVM, MD, or MS with significant industry experience in medicinal chemistry, pharmacology, toxicology, chemical biology, molecular biology, pharmaceutical sciences, or biochemistry
- Hands‑on experience in drug discovery or safety assessment including target validation through lead optimization
- Experience in structure–activity relationship analysis
- Experience in pharmacokinetics and ADME interpretation
- Experience in toxicology and safety pharmacology studies
- Experience interpreting in vitro and in vivo experimental data
- Strong expertise in target biology and mechanism‑of‑action reasoning
- Understanding of dose‑response relationships and exposure margins
- Ability to interpret translational relevance between preclinical and clinical findings
- Knowledge of toxicity mechanisms such as liver toxicity, cardiovascular liabilities, genotoxicity, or reproductive toxicity
- Ability to evaluate safety findings for risk and program impact
- Experience reviewing primary experimental data and study reports
- Exceptional attention to scientific accuracy and mechanistic reasoning
- Experience in pharmaceutical or biotechnology drug discovery teams
- Background in lead optimization, translational biology, or nonclinical safety
- Familiarity with DMPK workflows, safety biomarkers, and regulatory toxicology considerations
- Experience contributing to cross‑functional discovery teams
- Exposure to AI or ML tools applied to biomedical research
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