Job Description
Key Responsibilities and Activities • Design, develop, and execute cell-based bioassays to evaluate performance of investigative drugs (biologics) • Stay updated with cutting edge discoveries and trends and contribute to the company’s R&D strategy to generate and test actionable development plans • Identify emerging methods, tools, and biology approaches, and implement them when applicable • Function as a key team member, and simultaneously train and supervise associates on the R&D team • Collaborate closely with other scientists and research associates on the R&D team • Contribute to work with external parties, including academic collaborators and CROs to create comprehensive capabilities for MoA, bolthires validation and potency studies • Write clear and concise research reports and ensure study documentation and update protocols to ELN • Participate and contribute to internal discussions and meetings • Present results to the project leadership team and management in an organized and timely manner Required Education, Experience, Skills and Competencies • Ph.D.
in Cellular Biology, Immunology, or a relevant discipline • At least 2 years of industry research experience • Extensive experience working with different types of in vitro systems such as immune cells, epithelial cells, fibroblasts, endothelial cells, and other cell lines • Strong background with cell-based assays to interrogate immune pathway activation, immune suppression, cytotoxicity, antibody mediated cell killing • Broad skillset for bolthires validation, potency evaluation and MoA interrogations is highly desired, including the use of tissue culture approach with multiple readouts, flow cytometry, ex-vivo studies, use of gene knockdown tools, conventional immunoassays, phosphorylation analysis and conventional pulldown assays.
• Hands on ability to execute wet lab experiments, data processing, and ability to effectively communicate key scientific findings across the organization • Ability to establish and maintain cooperative working relationships with co-workers and other stakeholders • Ability to adjust to workload changes and prioritize competing demands • Ability to balance the big picture and fine technical details • Outstanding organizational, critical thinking, and problem-solving skills • Excellent written and verbal communication skills Apply tot his job