Bioinformatician I

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The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary SUMMARY: We are seeking a highly motivated Bioinformatics Specialist to join our research team. This position will focus on implementing and maintaining the hardware and software infrastructure for deep leaning, high-dimensional image analysis using proteomic, genomic and transcriptomic data analysis, and data management/husbandry. The successful candidate will work closely with biologists, computational scientists, and clinicians to extract meaningful insights from multimodal datasets.

KEY RESPONSIBILITIES: 1. Data Management & Computational Infrastructure • Develop and maintain data pipelines for large-scale imaging and sequencing datasets. • Set up and maintain multi-user GPU/HPC infrastructure for large-scale multi-omics analysis and deep learning model training/inference. • Manage data storage, versioning, and retrieval in compliance with FAIR data principles. • Maintain documentation and reproducible workflows using Snakemake, Nextflow, or WDL. 2. Multiplex Immunofluorescence Image Analysis & Spatial Biology • Develop and implement workflows for Lunaphore COMET and Singular Genomics G4X multiplexed immunofluorescence image analysis.

• Process and analyze high-dimensional imaging datasets using QuPath, ImageJ, Cellpose, and other computational tools. • Integrate spatial biology data with transcriptomic/genomic data for multimodal analysis. 3. Genomic & Transcriptomic Data Analysis • Develop and implement workflows for bulk RNA-seq, single-cell RNA-seq (scRNA-seq), and spatial transcriptomics data analysis. • Conduct Next-Generation Sequencing (NGS) analysis, including variant calling, gene expression analysis, and pathway enrichment studies.

• Utilize bioinformatics pipelines (e.g., STAR, Cell Ranger, Seurat, DESeq2, Monocle, Scanpy) for data processing. • Work with long-read sequencing (PacBio, Oxford Nanopore) and epigenomics as needed. Qualifications

Required Skills & Qualifications MSc or PhD (or BSc with equivalent experience) in Bioinformatics, Computational Biology, Biostatistics, or related field. Proficiency in Python, R, Java/Groovy and Bash scripting. Familiarity with containerized environments (e.g. Docker, Apptainer). Familiarity with machine learning / AI for image and genomic data analysis.

Experience working in Unix/Linux environments and using HPC/cloud-based pipelines. Strong organizational skills for handling large and complex datasets. Ability to collaborate effectively in a multidisciplinary research team. Additional Job Details (if applicable)

Remote Type Onsite Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $73,798.40 - $107,400.80/Annual Grade 6 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization.

Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth.

We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: 1200

The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level.

The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts.

Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system.

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