Clinical SME – Design Controls Remediation

🌍 Remote, USA 🎯 Full-time 🕐 Posted Recently

Job Description

Role Summary

We are seeking a Senior Clinical Subject Matter Expert (SME) with 8–10+ years of experience to support Design Controls Remediation initiatives. The ideal candidate will possess an advanced clinical degree and deep expertise in medical device clinical research, with a strong focus on regulatory compliance and clinical evidence generation.

    Key Responsibilities
  • Perform gap analyses on clinical study plans, protocols, and datasets against design control and regulatory requirements
  • Support development of Clinical Evaluation Reports (CERs), risk-benefit assessments, and post-market clinical follow-up (PMCF) strategies
  • Ensure alignment of clinical data with validation protocols and user needs documentation
  • Provide clinical justification for design updates during remediation activities
  • Collaborate cross-functionally with Pre-Clinical SMEs and Systems Engineering teams to build a robust evidence strategy
    Required Qualifications
  • Advanced clinical degree (MD, PhD, or equivalent)
  • 8–10+ years of experience in medical device clinical research
  • Hands-on experience with clinical trials or clinical evaluations under ISO 14155 and FDA regulations
  • Strong expertise in clinical risk management and regulatory evidence generation
  • Prior experience in clinical gap remediation, Design History File (DHF), or pre-market approval (PMA) projects
  • Solid background in clinical study design and data analysis
    Ideal Candidate Profile
  • Experience working on design control remediation programs
  • Strong understanding of regulatory submissions and compliance frameworks
  • Ability to work independently in a remote, cross-functional environment

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