Job Description
Note: The job is a remote job and is open to candidates in USA. Twist Bioscience is a company focused on synthesizing genes from scratch, contributing to advancements in various fields including health care and agriculture. They are seeking a Senior Bioinformatics Engineer with expertise in Nextflow and AWS to architect and optimize bioinformatics pipelines for large-scale NGS data processing. Responsibilities • Architect and develop advanced Nextflow pipelines for NGS data processing, analysis, and multi-step workflow orchestration • Deploy, operate, and optimize pipelines on AWS EKS and Batch • Build and maintain Docker-based container environments for reproducible and portable bioinformatics pipelines • Develop and maintain robust Python tooling to support workflow automation, QC reporting, monitoring, and data integration • Implement workflow observability, logging, and cost-optimized execution strategies for large-scale genomic data • Collaborate with sequencing, bioinformatics, and platform engineering teams to improve workflow reliability and performance • Establish best practices for pipeline versioning, continuous integration, automated testing, and cloud-based deployment • Ensure pipelines are highly reproducible, fault-tolerant, and suitable for production environments in regulated or high-stakes settings Skills • 5+ years of experience in bioinformatics, computational biology, workflow engineering, or related fields • Expert-level proficiency in Nextflow, including DSL2, modules, workflow optimization, and pipeline debugging • Strong hands-on experience with AWS, particularly: EC2 compute environments, S3 for cloud storage, EKS for workflow execution • Deep expertise with Docker, including custom image creation, multi-stage builds, and best practices for pipeline reproducibility • Strong Python development skills with production-level experience, testing frameworks, packaging, and tooling • Experience operating in cloud-native environments with distributed computing, autoscaling, cost-optimization, and workflow orchestration • Solid understanding of NGS data formats, sequencing workflows, and common bioinformatics tools • Strong Linux skills and experience with CI/CD systems • Ability to work effectively in PST time zone (remote or onsite) • Experience with Java/Groovy • Experience building and using APIs • Experience with Nextflow Tower or similar workflow management platforms • Experience configuring Kubernetes workloads for genomics pipelines • Background in synthetic biology, DNA design, or high-throughput genomic library analysis • Experience collaborating with wet labs or platform teams on sequencing pipeline requirements Company Overview • Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries. It was founded in 2013, and is headquartered in San Francisco, California, USA, with a workforce of 501-1000 employees. Its website is Company H1B Sponsorship • Twist Bioscience has a track record of offering H1B sponsorships, with 18 in 2025, 14 in 2024, 22 in 2023, 19 in 2022, 4 in 2021, 6 in 2020. Please note that this does not guarantee sponsorship for this specific role. Apply tot his job